Substantial attention has been given in developing novel heterocyclic compounds as these have been
found to exhibit varied biological activities. Benzothiazoles belong to one of the special categories of heterocyclic
compounds with a wide range of biological activities such as antimicrobial, antitumor, antidiabetic, antitubercular,
antimalarial, anticonvulsant, anthelmintic, analgesic, antiinflammatory and many more. These compounds have
been serving as leads for researchers who are actively involved in synthesizing and evaluating their biological activities.
Such an extensive work has stimulated further development of new benzothiazole derivatives with enhanced
biological activities. This review focuses on the various approaches on the synthesis of benzothiazole derivatives
viz., conventional, green, combinatorial and microwave-assisted methods. It also highlights various biological
activities of the currently synthesized benzothiazoles.