Abstract
The extracellular matrix (ECM) is a complex network of proteins and glycosaminoglycans which surrounds cells and serves a critical role in directing cell fate and functions, as well as imparting the necessary mechanical behaviour to the tissue. To achieve successful cartilage regeneration, stem cells and/or progenitor cells have to be able to undergo an orderly spatiotemporal differentiation process, along with specific changes in the ECM expression and deposition, to form a cartilage tissue with the defined hierarchical matrix organization. In the last decade, significant advances have been made in our understanding of the role of the ECM during chondrogenesis and in cartilage homeostasis following differentiation, with some unexpected findings. This review will survey the major ECM components and their interactions with relevant stem cell populations for the regeneration of cartilage. Future therapies will likely benefit from a better understanding and a more precise control of stem cell-ECM interactions implicated in the regenerative response.
Keywords: Basement membrane, cartilage, biomaterials, extracellular matrix, stem cells, pericellular matrix, tissue regeneration.
Current Stem Cell Research & Therapy
Title:Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules
Volume: 11 Issue: 8
Author(s): Wei Seong Toh, Casper Bindzus Foldager, James Hoi Po Hui, Bjorn Reino Olsen and Myron Spector
Affiliation:
Keywords: Basement membrane, cartilage, biomaterials, extracellular matrix, stem cells, pericellular matrix, tissue regeneration.
Abstract: The extracellular matrix (ECM) is a complex network of proteins and glycosaminoglycans which surrounds cells and serves a critical role in directing cell fate and functions, as well as imparting the necessary mechanical behaviour to the tissue. To achieve successful cartilage regeneration, stem cells and/or progenitor cells have to be able to undergo an orderly spatiotemporal differentiation process, along with specific changes in the ECM expression and deposition, to form a cartilage tissue with the defined hierarchical matrix organization. In the last decade, significant advances have been made in our understanding of the role of the ECM during chondrogenesis and in cartilage homeostasis following differentiation, with some unexpected findings. This review will survey the major ECM components and their interactions with relevant stem cell populations for the regeneration of cartilage. Future therapies will likely benefit from a better understanding and a more precise control of stem cell-ECM interactions implicated in the regenerative response.
Export Options
About this article
Cite this article as:
Toh Seong Wei, Foldager Bindzus Casper, Hui Hoi Po James, Olsen Reino Bjorn and Spector Myron, Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules, Current Stem Cell Research & Therapy 2016; 11 (8) . https://dx.doi.org/10.2174/1574888X10666150723150525
DOI https://dx.doi.org/10.2174/1574888X10666150723150525 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Timely Review of State-of-the-Art Chronopharmaceuticals Synchronized with Biological Rhythms
Current Drug Delivery An Overview on Different Classes of Viral Entry and Respiratory Syncitial Virus (RSV) Fusion Inhibitors
Current Medicinal Chemistry miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis
Current Gene Therapy Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
Current Diabetes Reviews Cytotoxic T Lymphocyte Antigen 4 Gene +49 A/G (rs231775) Polymorphism and Susceptibility to Systemic Lupus Erythematosus
Current Rheumatology Reviews Evaluation of Salivary Melatonin Levels in HIV-positive Patients: A Historical Cohort Study
Reviews on Recent Clinical Trials Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases
Current Pharmaceutical Design Aggrecanase: The Family and Its Inhibitors
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Macrophage Migration Inhibitory Factor: A Therapeutic Target Across Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) MicroRNA-16-5p Controls Development of Osteoarthritis by Targeting SMAD3 in Chondrocytes
Current Pharmaceutical Design Clinical Uses of Melatonin: Evaluation of Human Trials
Current Medicinal Chemistry Potential Therapeutic Targets for Steroid-Resistant Asthma
Current Drug Targets Poly(ADP-Ribose) Polymerase Inhibitors: New Pharmacological Functions and Potential Clinical Implications
Current Pharmaceutical Design Computational Development of Selective nNOS Inhibitors: Binding Modes and Pharmacokinetic Considerations
Current Medicinal Chemistry Psoriasis and Vascular Risk : An Update
Current Pharmaceutical Design Bacterial Conjunctivitis in Childhood: Etiology, Clinical Manifestations, Diagnosis, and Management
Recent Patents on Inflammation & Allergy Drug Discovery Safety of Inhaled Corticosteroids. Why the Variation in Systemic Adverse Effects?
Current Pediatric Reviews Bone Disease - Current Knowledge and Future Prospects
Current Genomics Progress in Topical siRNA Delivery Approaches for Skin Disorders
Current Pharmaceutical Design The Molecular Control of Antigenic Variation in Trypanosoma brucei
Current Molecular Medicine