A large body of work has been published on transplantation of a wide range of neural stem and progenitor cell
types derived from the developing and adult CNS, as well as from pluripotent embryonic stem cells, in models of traumatic
spinal cord injury (SCI). However, many of these cell-based approaches present practical issues for clinical translation
such as ethical cell derivation, generation of potentially large numbers of homogenously prepared cells, and immune
rejection. With the advent of induced Pluripotent Stem (iPS) cell technology, many of these issues may potentially be
overcome. To date, a number of studies have demonstrated integration, differentiation into mature CNS lineages, migration
and long-term safety of iPS cell transplants in a variety of SCI models, as well as therapeutic benefits in some cases.
Given the clinical potential of this advance in stem cell biology, we present a concise review of studies published to date
involving iPS cell transplantation in animal models of SCI.