A series of new N’-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (1-
16) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and two nonpathogen
microorganisms. The target compounds were obtained with a multi-step reaction starting from 4-
substitutedarylhydrazine derivatives and the structures of final compounds have been elucidated with IR, NMR, Mass
spectroscopy data and elemental analysis results. The antifungal activity of the compounds was determined against eleven
different Fusarium, Trichoderma, Aspergillus and Penicilliumspeciesby using microdilution method. Most of the target
compounds showed excellent antifungal activity against a variety of fungal pathogens.
Keywords: Salicylidene hydrazide, 1, 2, 4-triazole, antifungal activity.
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