Metabolic Syndrome and Aging: Calcium Signaling as Common Regulator

Author(s): Maria Soprano, Maria Rosaria Rusciano, Michele Ciccarelli, Angela Serena Maione, Pietro Formisano, Maddalena Illario

Journal Name: Current Diabetes Reviews

Volume 12 , Issue 2 , 2016

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Aging is one of the most important societal challenges that western societies face, as a result of longer life expectancy and reduced natality rates. Aging is a success story of our health and social systems, but raises sustainability issues that are linked to the increased need for services of older adults, due to the reduction of their independence and to the co-existence of multiple chronic diseases. The metabolic syndrome can be considered an age-related disease, since its prevalence increases with age. Current demographic trends in the population highlight aging-related dysfunctions that contribute to the onset of several metabolic diseases, and the need for innovative, effective and sustainable approaches. This review describes the correlation between the metabolic syndrome and aging, and the underlying common molecular mechanisms, focusing on calcium signaling and its crosstalks.

Keywords: Aging, calcium signaling, frailty, and metabolic syndrome.Aging, calcium signaling, frailty, and metabolic syndrome.

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Article Details

Year: 2016
Published on: 18 November, 2015
Page: [84 - 89]
Pages: 6
DOI: 10.2174/1573399811666150722124701
Price: $65

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PDF: 30
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