Natural products from animal venoms have been used widely in the discovery
of novel molecules with particular biological activities that enable their use as potential
drug candidates. The phylum Cnidaria (jellyfish, sea anemones, corals zoanthids,
hydrozoans, etc.) is the most ancient venomous phylum on earth. Its venoms are
composed of a complex mixture of peptidic compounds with neurotoxic and cytolitic properties that have shown activity
on mammalian systems despite the fact that they are naturally targeted against fish and invertebrate preys, mainly crustaceans.
For this reason, cnidarian venoms are an interesting and vast source of molecules with a remarkable activity on
central nervous system, targeting mainly voltage-gated ion channels, ASIC channels, and TRPV1 receptors. In this brief
review, we list the amino acid sequences of most cnidarian neurotoxic peptides reported to date. Additionally, we propose
the inclusion of a new type of voltage-gated sea anemone sodium channel toxins based on the most recent reports.