Effects of Creatine in Skeletal Muscle Cells and in Myoblasts Differentiating Under Normal or Oxidatively Stressing Conditions

Author(s): Piero Sestili, Elena Barbieri, Vilberto Stocchi

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 16 , Issue 1 , 2016

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Abstract:

Creatine (Cr) - along with the Cr kinase (CK) system - plays a fundamental role in muscle biochemistry and physiology not limited to its ergogenic role. Indeed, Cr has been shown to exert pleiotropic effects, which promote protein accretion, muscle-specific protein synthesis, growth in cultured myogenic cells and favour the myogenic process either in normal or stressing conditions. This review focuses on the effects of Cr supplementation on cellular and mitochondrial biochemistry and function in the course of skeletal muscle differentiation, either in normal or oxidatively stressing conditions, and on the ensuing nutraceutical/therapeutic perspectives.

Keywords: Creatine, myogenesis, mitochondria, muscle diseases, skeletal muscle, supplementation.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2016
Page: [4 - 11]
Pages: 8
DOI: 10.2174/1389557515666150722102342
Price: $65

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