Creatine (Cr) - along with the Cr kinase (CK) system - plays a fundamental role in muscle
biochemistry and physiology not limited to its ergogenic role. Indeed, Cr has been shown to exert
pleiotropic effects, which promote protein accretion, muscle-specific protein synthesis, growth in
cultured myogenic cells and favour the myogenic process either in normal or stressing conditions.
This review focuses on the effects of Cr supplementation on cellular and mitochondrial biochemistry
and function in the course of skeletal muscle differentiation, either in normal or oxidatively stressing
conditions, and on the ensuing nutraceutical/therapeutic perspectives.
Keywords: Creatine, myogenesis, mitochondria, muscle diseases, skeletal muscle, supplementation.
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