Acute Respiratory Distress Syndrome-Past, Present and Future

Author(s): S. Manimala Rao, Kartik Munta

Journal Name: Current Respiratory Medicine Reviews

Volume 11 , Issue 3 , 2015


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Abstract:

For the past three to four decades, the onset of acute respiratory distress syndrome (ARDS) has brought substantial insight into its epidemiology and pathophysiology. It is characterised by an acute lung injury resulting in widespread pulmonary oedema due to increased alveolar capillary permeability. Acute lung injury arises from the damaging effects of inflammatory mediators. Treatment of ARDS involves various modalities of supportive care categorised as ventilator and nonventilator measures. Berlin’s conference consensus definition of ARDS has been widely accepted in defining and categorising ARDS. The promising therapies for future include use of statins, aspirin, nebulised heparin, AdrenoMedulin, Interferon beta, Tumour necrosis factor (TNF alpha) receptor blockade, Angiotensin converting enzyme and keratinocytes growth factors.

Keywords: ARDS, berlins definition, prone ventilation, restrictive fluid strategy, steroids, ventilator.

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2015
Published on: 10 November, 2015
Page: [231 - 235]
Pages: 5
DOI: 10.2174/1573398X11666150716172854
Price: $65

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