Cancer development is mostly due to a deregulation of cell death as cancer cells
become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging
to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for
cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects
aim to restore cancer cell death by using natural pharmacological scaffolds targeting
anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound
inhibitors of the Bcl-2 protein family with a focus on Mcl-1.
Keywords: apoptosis, cancer, Mcl-1, natural compounds.
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