Cardiovascular diseases (CVDs) have become a predominant cause of death worldwide. Although CVDs encompass
a variety of pathological conditions that affect the heart and blood vasculature, they can be classified into two
major groups according to their basic pathophysiologic mechanisms, namely atherosclerosis and aneurysm formation. Increasing
evidence implicates micro-RNAs (miRNAs or miRs) as vital factors both in the initiation and progression processes
of CVDs. Some miRs have a promoting role in CVD development, while others have a protective role. Today, miRs
have been shown to be potential biomarkers for several types of CVDs, while strategies targeting miRs are under consideration
as potential tools for exploitation in therapeutic approaches for CVD treatments. In this review, we present the
available data on the involvement of miRs in CVDs, focusing on their role as regulators of the inflammatory process as an
initiating and driving component of CVDs.
Keywords: Biomarkers, cardiovascular disease, inflammation, miRNAs.
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