Cognition and State Anxiety are Regulated by Thyroid Hormone Signaling

Author(s): Marc Fisher, Nandini Vasudevan.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
(Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

Volume 15 , Issue 1 , 2015


Anxiety and cognition are both linked to deficits in thyroid hormone concentrations in humans and in rodent models. Both processes have also been shown to be affected by the loss of the thyroid hormone receptors (TR) or by mutant transgenic TRs. Specifically, the unbalanced action of the unliganded TRα1 is thought to be important in the memory deficit and extreme anxiety seen in transgenic mice. The contribution of TRβ is less well defined and the molecular mechanisms that underlie these deficits are also unknown. We review the literature that demonstrates the importance of the thyroid hormone (TH) and the TR in these processes and focus on the mechanisms, in particular adult hippocampal neurogenesis in the dentate gyrus, that might be important in mediating both state anxiety and cognition by thyroid hormone.

Keywords: Thyroid hormone receptors, neurogenesis, spatial memory, BDNF, anxiety.

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Article Details

Year: 2015
Page: [60 - 70]
Pages: 11
DOI: 10.2174/187152221501150710130829

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