Editorial: microRNAs: Potential Targets for the Treatment of Cardiovascular Disease

Author(s): Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis

Journal Name: Current Vascular Pharmacology

Volume 13 , Issue 3 , 2015

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Several non-coding microRNAs (miRs) are implicated in the pathogenesis of obesity, metabolic syndrome, diabetes mellitus, atherosclerosis and cardiovascular disease. Some of these miRs are beneficial but others are hazardous. Silencing of the latter by antisense oligonucleotides has been attempted in animal models with promising results. However, the replacement of down-regulated beneficial miRs, by manufactured miR mimics, or increasing their expression is much more demanding and has several limitations. The treatment of cardiovascular diseases through miR manipulation shows potential, provided safety and cost effectiveness issues are considered carefully before implementation in humans.

Keywords: microRNA, cardiovascular disease, obesity, metabolic syndrome, diabetes, antisense oligonucleotides, silencing, microRNA mimics.

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Article Details

Year: 2015
Page: [366 - 367]
Pages: 2
DOI: 10.2174/157016111303150707103801

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