Angiogenesis plays an important role in the treatment of acute myocardial infarction (MI). Formation of
micro-vessels has the potential to prevent apoptosis of the ischemic myocardium and to improve cardiac function
after MI. Delivery of growth factors or administration of stem/progenitor cells (mainly from bone marrow) are the
dominant therapies to induce angiogenesis after MI. Nevertheless, clinical trials have shown that delivery of a single
growth factor or single type of cell does not provide sufficient angiogenesis to promote cardiac repair. Circadian
rhythms control many physiological and pathological processes in mammals. Many studies show a close relationship
between circadian rhythms and MI. Disruption of the circadian rhythms in humans leads to increased incidence
of MI. The onset and infarct area of MI are markedly elevated at certain time points. Determining the mechanisms of angiogenesis
and vessel maturation in the ischemic heart under the control of circadian rhythms could help in the development of novel and angiogenesis-
targeted therapeutics for the treatment of MI.
Keywords: Angiogenesis, circadian rhythms, myocardial infarction, period 2.
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