Disruption of Circadian Rhythms in Critical Illness - A Role of Hyperoxia-Induced Lung Injury

Author(s): Alexander Czachor, Zachary Krueger, Young Cho, Sarvadaman Pathak, Yashwant Pathak, Richard Lockey, Narasaiah Kolliputi

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 24 , 2015


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Abstract:

With the current high rates of associated morbidity and mortality, proper management of critical illness is vital in the treatment of severely ill patients. Disruptions of key body systems stemming from these illnesses may be attributed to their severity and limited treatment options. Disruption in circadian rhythms caused by critical illnesses may lead to a decreased patient prognosis, as the biological clocks stemming from circadian rhythms play several key roles in regulating our internal pathways. This review will highlight how the occurrence of hyperoxic injury during the progression of critical illness may severely damage circadian rhymicity, and lead to an increased risk of infection, development of disease, severity of symptoms, morbidity and mortality, and dysregulation of multiple body systems. Overall, there is strong evidence suggesting that the disruption of circadian rhythms may be caused by critical illness. Studies performed on several animal models have shown alterations of key genes associated with circadian clock function may heavily contribute to the increased severity of critical illness linked to circadian disruption. This review will aid in further understanding the link between circadian disruption and critical illness.

Keywords: Clock genes, inflammation, oxidative stress, respiratory disease, ROS.

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Article Details

VOLUME: 21
ISSUE: 24
Year: 2015
Published on: 09 August, 2015
Page: [3489 - 3495]
Pages: 7
DOI: 10.2174/1381612821666150706105330
Price: $65

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