Title:Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
VOLUME: 15 ISSUE: 9
Author(s):Leyla Yurttas, Seref Demirayak and Gulsen Akalın Ciftci
Affiliation:Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Keywords:Antiproliferative, apoptosis, benzimidazole, cytotoxicity.
Abstract:Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry.
Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As
a continuation to our previous work, we have synthesized a new series of 1-(2-aryl-2-oxoethyl)-2-[(N,Ndimethylamino/
pyrrolidinyl/piperidinyl)thiocarbamoyl] benzimidazole derivatives. Anticancer activity of the
compounds was evaluated using MTT assay, BrdU assay and flow cytometric analysis on A549 human lung
carcinoma and C6 rat glioma cell lines. Compounds bearing dimethylamino moiety exhibited higher antitumor
activity.
