Some new trifluoromethyl coumarin thiosemicarbazones 3a-3m were synthesized by condensation
reaction of thiosemicarbazides and 3-trifluoroacetyl coumarins which was from recyclization
of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates under microwave assisted
and solvent-free conditions. The structure of the synthesized compounds were characterized by IR, 1H
NMR, 13C NMR, HRMS and X-ray, and their antifungal activity was evaluated. Most of them exhibited
potent antifungal activity by comparison with the standard drugs.