Microwave Assisted One-Pot Synthesis of Novel Trifluoromethyl Coumarin Thiosemicarbazones and their Antifungal Activities

Author(s): Guoyu Yang, Cuilian Xu, Mingqin Zhao, Caixia Wang, Sufang Fan, Puhui Xie, Xin Li

Journal Name: Current Microwave Chemistry

Volume 3 , Issue 1 , 2016

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Graphical Abstract:


Some new trifluoromethyl coumarin thiosemicarbazones 3a-3m were synthesized by condensation reaction of thiosemicarbazides and 3-trifluoroacetyl coumarins which was from recyclization of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates under microwave assisted and solvent-free conditions. The structure of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, HRMS and X-ray, and their antifungal activity was evaluated. Most of them exhibited potent antifungal activity by comparison with the standard drugs.

Keywords: Antifungal activity, microwave synthesis, one-pot synthesis, solvent-free, trifluoromethyl coumarin thiosemicarbazones.

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Article Details

Year: 2016
Published on: 30 October, 2015
Page: [60 - 67]
Pages: 8
DOI: 10.2174/2213335602666150702161715

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PDF: 44