Application of Sustained-release Carrier of NanoAg-Epidermal Growth Factor in Promoting Refractory Diabetic Wound Healing

Author(s): Ning-ning Tang, Feng Hu, Jin-yan Liu, Can Liu, Chao-qi Yin, Yong Chen, Jian-da Zhou

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 2 , 2016

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Abstract:

Objective: This study aimed to elucidate the antibacterial properties and therapeutic effect in refractory diabetic wound healing of a NanoAg-epidermal growth factor sustained-release carrier(NanoAg-EGF).

Methods: as previous publishing, the sustained-release carrier of NanoAg-EGF can be conducted. The antibacterial properties and therapeutic effects of NanoAg-EGF were determined through in vitro bacterial growth inhibition experiments and in vivo wound healing experiments in diabetic rats.

Results: In antibacterial experiments, NanoAg-EGF had strong properties of antibacterial which is similar to those of NanoAg (p>0.05). In diabetic wound healing experiments, NanoAg-EGF significantly shortened the wound healing time. Furthermore, at 3 days after wounding, the healing rate of each group was no different (p>0.05). However, at 7 and 13 days after wounding, with being higher than other four groups, the healing rates of sustained-release carrier treated diabetic rats were remarkable (p<0.05).

Conclusion: NanoAg-EGF not only has good antibacterial properties, but can also promote rapid wound healing in diabetes.

Keywords: Antibacterial, diabetes, epidermal growth factor, NanoAg, NanoAg-EGF, wound healing.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2016
Page: [135 - 140]
Pages: 6
DOI: 10.2174/1570180812666150630183147
Price: $65

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