They Must Hold Tight: Junction Proteins, Microbiota And Immunity In Intestinal Mucosa

Author(s): Angela Castoldi, Cristhiane Favero de Aguiar, Pedro Manoel Moraes-Vieira, Niels Olsen Saraiva Câmara

Journal Name: Current Protein & Peptide Science

Volume 16 , Issue 7 , 2015

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Graphical Abstract:


Homeostasis of the immune system depends on several factors. The gastrointestinal tract plays an important role in maintaining our immune system. With this aim, the intestinal immune system interacts with epithelial barrier molecules, especially tight junction proteins, that are key molecules involved in controlling paracellular permeability to increase the protection barrier against external antigens or possibly to respond to commensal microorganisms. During intestinal inflammatory diseases, the expression of innate immune receptors in intestinal epithelial cells and infiltration of immune cells are related, but it is still unclear how the immune system induces modulation of paracellular permeability. In this review, we provide an overview of the understanding of how the immune system modulates the expression of tight junctions to maintain the mucosal immune system.

Keywords: Gut microbiota, immune system, intestinal epithelium, intestinal permeability, tight junctions.

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Article Details

Year: 2015
Published on: 10 August, 2015
Page: [655 - 671]
Pages: 17
DOI: 10.2174/1389203716666150630133141
Price: $65

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