Apoptosis is a prominent characteristic in the pathogenesis of liver disease. The molecular
mechanism of hepatic apoptosis is not well understood. Liver injury induces a downregulation of hepatocyte
nuclear factor 6 (HNF6) that is negatively correlated with the degree of apoptosis. However, an enhancement
of HNF6 can relieve hepatic apoptosis and impede the progression of liver disease. HNF6 has distinct
mechanisms to modulate hepatic apoptosis. Pathophysiological role of HNF6 may be apoptosis-resistant and
liver-protective during different types of liver injury. The enhancing modality of HNF6 is a novel therapeutic
intervention for liver disease.
Keywords: Hepatic apoptosis, HNF6, liver injury, nuclear factor.
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