Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in the pediatric
population and recapitulates many of the phenotypic and biological features of embryonic skeletal
muscle. RMS is pathologically characterized by myogenic differentiation arrest. Dysregulation of
pathways essential for myogenesis like contribute to the tumorigenesis of RMS. The Wnt signaling
pathway is one of the major pathways required for normal myogenesis. Aberrant Wnt signaling has
also been demonstrated in many types of cancer. The role of Wnt pathway in the pathogenesis of RMS
is beginning to be appreciated. This review will go over current knowledge on biological roles of Wnt
pathway in RMS and potential translational application in therapeutics.
Keywords: Wnt, rhabdomyosarcoma, cancer, myogenesis.
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