Wnt Signaling in Rhabdomyosarcoma – A Potential Targeted Therapy Option

Author(s): Eleanor Chen

Journal Name: Current Drug Targets

Volume 17 , Issue 11 , 2016

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Graphical Abstract:


Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in the pediatric population and recapitulates many of the phenotypic and biological features of embryonic skeletal muscle. RMS is pathologically characterized by myogenic differentiation arrest. Dysregulation of pathways essential for myogenesis like contribute to the tumorigenesis of RMS. The Wnt signaling pathway is one of the major pathways required for normal myogenesis. Aberrant Wnt signaling has also been demonstrated in many types of cancer. The role of Wnt pathway in the pathogenesis of RMS is beginning to be appreciated. This review will go over current knowledge on biological roles of Wnt pathway in RMS and potential translational application in therapeutics.

Keywords: Wnt, rhabdomyosarcoma, cancer, myogenesis.

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Article Details

Year: 2016
Published on: 28 July, 2016
Page: [1245 - 1251]
Pages: 7
DOI: 10.2174/1389450116666150630110625
Price: $65

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