Background: Cardiovascular diseases, especially ischemic heart disease and cardiometabolic
disease, remain to be the leading cause of morbidity and mortality worldwide. Despite recent
progress in diagnostic and therapeutic approaches, the incidence of cardiovascular disease is still rising.
Therefore, alternative favorable treatment is urgently needed to rescue the fast growing numbers
Objective: Herein we aimed to review the relevant role and explore the possibility of SIRT1 as a promising
target for protection of heart from ischemia/reperfusion injury and cardiometabolic diseases.
Results: The activation of SIRT1 participates in a variety of important metabolic and physiologic
processes including stress resistance, metabolism, apoptosis and energy balance in heart ischemia injury
and cardiometabolic disease.
Conclusion: Current medication targeting SIRT1 may represent a new therapeutic trend for the prevention
of cardiovascular disease that is related to energy balance and metabolism.