Immunomodulatory Effects of Soybeans and Processed Soy Food Compounds

Author(s): Hiroyuki Tezuka, Shinjiro Imai

Journal Name: Recent Patents on Food, Nutrition & Agriculture
Continued as Recent Advances in Food, Nutrition & Agriculture

Volume 7 , Issue 2 , 2015

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Graphical Abstract:


Inflammation is an immune response against both internal and external antigens in organisms, particularly in mammals, and includes both uncontrolled chronic and low-grade inflammations. Uncontrolled chronic inflammation often leads to severe diseases such as vascular disease, arthritis, cancer, diabete, allergy, and autoimmunity. On the other hand, low-grade inflammation is recognized as a relationship between obesity and risk of metabolic syndrome. Elevated production of pro-inflammatory cytokines and mediators is commonly observed in patients with uncontrolled or low-grade inflammation-associated diseases. Plants have been generated phytochemicals to overcome inflammations and infections through evolution. Phytochemicals belong to alkaloids, polyphenols, flavonoids, coumarins, and terpenoids. The consumption of soybeans plays a role in immune modulation through their components such as isoflavones, saponins, and anthocyanins. Recently, it was reported that the application of phytochemicals into patients with inflammatory diseases improves their symptoms. Therefore, it is important to identify novel phytochemicals with immunomodulatory activities. This review introduces and discusses recent advances and patents regarding soybean or processed soy food compounds which exhibit immunomodulatory activity in immune diseases, particularly allergy, by mediating the suppression of inflammatory pathways.

Keywords: Anti-inflammatory, flavonoid, inflammation, isoflavone, saponin, soybean.

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Article Details

Year: 2015
Published on: 27 September, 2015
Page: [92 - 99]
Pages: 8
DOI: 10.2174/2212798407666150629123957
Price: $65

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