Tetrandrine (Ted) has been demonstrated in a series of studies to have potential antitumor effect against several
cancers. Its lipophilicity makes it an ideal model drug for nanoparticle encapsulation. We constructed Ted loaded
nanoparticles (Ted-NP) with PLGA-PEG as drug carrier. Characterization of the nanoparticles showed that Ted-NP had a
size of less than 100 nm and a slight negative surface charge. By adjusting the feeding ratio, the highest drug loading
content and encapsulation efficiency were 13.6% and 87.2%, respectively. In vitro release indicated the sustained release
pattern of Ted-NP. In vitro cytotoxicity test demonstrated that Ted-NP showed stronger cell growth inhibitory effect than
free Ted did at equivalent doses. The antitumor effect was mediated by induction of apoptosis through a mitochondrial
way. Therefore, the characteristic of amphiphilic copolymer based drug delivery system enables a more efficient way to
deliver Ted for cancer treatment.
Keywords: Larynx cancer, nanoparticle, PLGA-PEG, tetrandrine.
Rights & PermissionsPrintExport