Nano-Tetrandrine Efficiently Inhibits the Proliferation and Induces the Apoptosis of Hep2 Cells through a Mitochondrial Signaling Pathway

Author(s): Yu Wang, Huiping Ye, Haitao Yin

Journal Name: Current Signal Transduction Therapy

Volume 10 , Issue 2 , 2015

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Graphical Abstract:


Tetrandrine (Ted) has been demonstrated in a series of studies to have potential antitumor effect against several cancers. Its lipophilicity makes it an ideal model drug for nanoparticle encapsulation. We constructed Ted loaded nanoparticles (Ted-NP) with PLGA-PEG as drug carrier. Characterization of the nanoparticles showed that Ted-NP had a size of less than 100 nm and a slight negative surface charge. By adjusting the feeding ratio, the highest drug loading content and encapsulation efficiency were 13.6% and 87.2%, respectively. In vitro release indicated the sustained release pattern of Ted-NP. In vitro cytotoxicity test demonstrated that Ted-NP showed stronger cell growth inhibitory effect than free Ted did at equivalent doses. The antitumor effect was mediated by induction of apoptosis through a mitochondrial way. Therefore, the characteristic of amphiphilic copolymer based drug delivery system enables a more efficient way to deliver Ted for cancer treatment.

Keywords: Larynx cancer, nanoparticle, PLGA-PEG, tetrandrine.

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Article Details

Year: 2015
Published on: 14 September, 2015
Page: [89 - 94]
Pages: 6
DOI: 10.2174/1574362410666150625190515
Price: $65

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