The Clinical Significance of Indocyanine Green Excretion Test in Evaluation of Liver Functional Reserve

Author(s): Yu Wei, Qiu Yunqing, Ying Chaoqun

Journal Name: Current Signal Transduction Therapy

Volume 10 , Issue 2 , 2015

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Graphical Abstract:


Post-operative liver failure is the deterioration of liver function following liver resection with high mortality. To assure safe liver treatment, accurate preoperative estimation of the functional reserve is crucial. Although the hepatic functional reserve is generally evaluated by the model for endstage liver disease (MELD) scores and Child-Pugh classification, their accuracy is unsatisfactory. In recent years, indocyanine green(ICG) excretion test is commonly used to examine the kinetics of liver function and possess considerable advantages. ICG, a near-infrared fluorophore, has high uptake and retention in liver. The distribution and elimination of ICG was measured using pulse dye densitometry by transcutaneous measurements, which is minimally invasive and automated. There are some studies concerning the clinical significance of the ICG excretion test showed that ICGR15 (indocyanine green retention rate at 15 minutes) is a sensitive indicator of liver function. The aims of this study were to compare the predictive value of ICG excretion test with Child- Pugh classification and MELD scores, and investigate the risk factors for hepatic insufficiency after treatment, which could provide more convenient and reliable method for evaluating liver functional reserve.

Keywords: Child-Pugh classification, hepatic dysfunction, ICG excretion test, MELD scores.

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Article Details

Year: 2015
Published on: 25 June, 2015
Page: [140 - 145]
Pages: 6
DOI: 10.2174/1574362410666150625185126
Price: $65

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PDF: 16