Title:The Clinical Significance of Indocyanine Green Excretion Test in Evaluation of Liver Functional Reserve
VOLUME: 10 ISSUE: 2
Author(s):Yu Wei, Qiu Yunqing and Ying Chaoqun
Affiliation:State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital,College of Medicine, Zhejiang University, China.
Keywords:Child-Pugh classification, hepatic dysfunction, ICG excretion test, MELD scores.
Abstract:Post-operative liver failure is the deterioration of liver function following liver resection
with high mortality. To assure safe liver treatment, accurate preoperative estimation of the functional
reserve is crucial. Although the hepatic functional reserve is generally evaluated by the model for endstage
liver disease (MELD) scores and Child-Pugh classification, their accuracy is unsatisfactory. In
recent years, indocyanine green（ICG） excretion test is commonly used to examine the kinetics of
liver function and possess considerable advantages. ICG, a near-infrared fluorophore, has high uptake
and retention in liver. The distribution and elimination of ICG was measured using pulse dye densitometry by
transcutaneous measurements, which is minimally invasive and automated. There are some studies concerning the clinical
significance of the ICG excretion test showed that ICGR15 (indocyanine green retention rate at 15 minutes) is a sensitive
indicator of liver function. The aims of this study were to compare the predictive value of ICG excretion test with Child-
Pugh classification and MELD scores, and investigate the risk factors for hepatic insufficiency after treatment, which
could provide more convenient and reliable method for evaluating liver functional reserve.
