Abstract
In the current context of antiviral drug development, which has been traditionally dominated by herpesviruses, human immunodeficiency virus (HIV) and hepatitis C virus (HCV), a new viral target has been recently gained unforeseen attention, Ebola virus. Ten nucleoside analogues, or categories thereof, are reviewed for their therapeutic potential as antiviral drugs: (i) BCX4430, a C-nucleoside; (ii) 4’-azido-, 4’-cyano-, and 4’-ethynyl derivatives; (iii) 4’-thionucleosides; (iv) cordycepin (3’-deoxyadeosine); (v) pyrazofurin, another C-nucleoside; (vi) neplanocin A analogues; (vii) EICAR, a ribavirin analogue; (viii) GR-92938X, a double carboxamide; (ix) sofosbuvir (Solvaldi®), a 2’-C-methylnucleoside; and (x) favipiravir (T-705), a pyrazine analogue.
Keywords: 2’-C-methyl, 4’-azido- and 4’-cyano substituents, 4’-ethynyl, 4-thionucleoside, C-nucleoside, carboxamide, pyrazine.
Current Medicinal Chemistry
Title:Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential
Volume: 22 Issue: 34
Author(s): Erik De Clercq
Affiliation:
Keywords: 2’-C-methyl, 4’-azido- and 4’-cyano substituents, 4’-ethynyl, 4-thionucleoside, C-nucleoside, carboxamide, pyrazine.
Abstract: In the current context of antiviral drug development, which has been traditionally dominated by herpesviruses, human immunodeficiency virus (HIV) and hepatitis C virus (HCV), a new viral target has been recently gained unforeseen attention, Ebola virus. Ten nucleoside analogues, or categories thereof, are reviewed for their therapeutic potential as antiviral drugs: (i) BCX4430, a C-nucleoside; (ii) 4’-azido-, 4’-cyano-, and 4’-ethynyl derivatives; (iii) 4’-thionucleosides; (iv) cordycepin (3’-deoxyadeosine); (v) pyrazofurin, another C-nucleoside; (vi) neplanocin A analogues; (vii) EICAR, a ribavirin analogue; (viii) GR-92938X, a double carboxamide; (ix) sofosbuvir (Solvaldi®), a 2’-C-methylnucleoside; and (x) favipiravir (T-705), a pyrazine analogue.
Export Options
About this article
Cite this article as:
Clercq De Erik, Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential, Current Medicinal Chemistry 2015; 22 (34) . https://dx.doi.org/10.2174/0929867322666150625094705
DOI https://dx.doi.org/10.2174/0929867322666150625094705 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ovarian Cancer Biomarkers: A Focus on Genomic and Proteomic Findings
Current Genomics Targeted Tumor Diagnosis and Therapy with Peptide Hormones as Radiopharmaceuticals
Anti-Cancer Agents in Medicinal Chemistry From NAFLD to NASH and HCC: Pathogenetic Mechanisms and Therapeutic Insights
Current Pharmaceutical Design Surgical Treatment of Endometriosis
Current Women`s Health Reviews Non-histone Methylation of SET7/9 and its Biological Functions
Recent Patents on Anti-Cancer Drug Discovery The Adipose Tissue as a Source of Vasoactive Factors
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Tissue Fatty Acid Profile is Differently Modulated from Olive Oil and Omega-3 Polyunsaturated Fatty Acids in ApcMin/+ Mice
Endocrine, Metabolic & Immune Disorders - Drug Targets DNA Demethylation by TET Proteins: A Potential Therapeutic Target in Cancer
Epigenetic Diagnosis & Therapy (Discontinued) Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy
Current Cancer Drug Targets Nuclear Imaging of Hormonal Receptor Status in Breast Cancer: A Tool for Guiding Endocrine Treatment and Drug Development
Current Cancer Drug Targets The Role of Melanocortin Peptides and Receptors in Regulation of Energy Balance
Current Pharmaceutical Design Biomarkers to Assess the Targeting of DNA Repair Pathways to Augment Tumor Response to Therapy
Current Molecular Medicine The Therapeutic Potential of Targeting Autophagy in the Treatment of Cancer
Current Cancer Drug Targets Inhibition of RET Activated Pathways: Novel Strategies for Therapeutic Intervention in Human Cancers
Current Pharmaceutical Design Novel Approaches to Cancer Therapy Using Oncolytic Viruses
Current Molecular Medicine Molecular Insights into the Mechanisms Underlying the Cholesterol- Lowering Effects of Phytosterols
Current Medicinal Chemistry Gender Disparity in Pediatric Diseases
Current Molecular Medicine The Role of Diabetes Mellitus in Diseases of the Gallbladder and Biliary Tract
Current Diabetes Reviews FDG-PET/CT and SPECT/CT in Oncology
Current Medical Imaging Carbonic Anhydrase IX as an Anticancer Therapy Target: Preclinical Evaluation of Internalizing Monoclonal Antibody Directed to Catalytic Domain
Current Pharmaceutical Design