Left Ventricular 2-[18F]-Fluoro-2-Deoxy-D-Glucose Uptake Using Modified Oral Glucose Loading Protocol With Pre-Medicated Niacin On Positron Emission Tomography/Computed Tomography - A Preliminary Study

Author(s): Mohd Nazmi Nordin, Abdul Jalil Nordin, Fathinul Fikri Ahmad Saad, Hairil Rashmizal Abdul Razak

Journal Name: Current Molecular Imaging (Discontinued)

Volume 3 , Issue 3 , 2014

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Abstract:

There are several protocols in the clinical assessment of myocardial viability using 18FFDG PET/CT. This study assessed the intensity of 18F-FDG uptake in the wall of LV using a modified protocol in one group (Group A) consisting of 11 volunteers compared with another group (Group B) consisting of 11 patients who underwent 18F-FDG whole body (WB) PET/CT for oncology reasons. The 18F-FDG uptake in the wall of LV was qualitatively and quantitatively assessed. The mean age for group A and B were 35.00 ± 11.91 and 45.91 ± 14.58 respectively. The LV uptake of 18F-FDG was significantly increased in Group A. There was a significant difference in mean SUVmax at basal (8.28 ± 3.88 vs 3.79 ± 2.92, p=0.006), mid (5.32 ± 3.48 vs 3.71 ± 2.16, p=0.047), and apical (7.39 ± 3.57 vs 3.84 ± 2.82, p=0.018) segments of LV. The mean normalized 18F-FDG distribution in 20-segment polar map expressed in percentage for group B was lower in comparison to group A (61.02% vs 72.28%, p=0.034). Niacin can be utilized in combination with glucose loading protocol to enhance glucose uptake using 18F-FDG PET/CT.

Keywords: Glucose uptake, myocardial viability, niacin, PET/CT.

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2014
Page: [246 - 251]
Pages: 6
DOI: 10.2174/2211555204666150622171653
Price: $58

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