Diabetes is a chronic disease that affects more than 387 million people worldwide. About
20% of patients diagnosed with diabetes develop diabetic foot ulcerations (DFU). Standard treatment
of DFU includes wound debridement, infection control, revascularization and, in general, the acceleration
of the healing process. Topical ointments containing flavonoids exert beneficial effects in wound
healing process. Flavonoids increase the migration and proliferation of fibroblasts and collagen synthesis.
Furthermore, most flavonoids exert antibacterial and astringent activities that help in infection
control. Additionally, flavonoids possess antioxidant and anti-inflammatory activities reducing the reactive
oxygen species and modulating the inflammatory pathways, respectively. Bioactivity of flavonoids can vary according
to source, chemical structure and glycosylation pattern. In summary, topical application of flavonoids reduces epithelialization
and wound closure time of DFU in diabetic patients.