Heterocyclic N-Oxides - An Emerging Class of Therapeutic Agents

Author(s): A.M. Mfuh, O.V. Larionov

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 24 , 2015

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Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial, antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and procognitive activities. The N-oxide motif has been successfully employed in a number of recent drug development projects. This review surveys the emergence of this scaffold in the mainstream medicinal chemistry with a focus on the discovery of the heterocyclic N-oxide drugs, N-oxide-specific mechanisms of action, drug-receptor interactions and synthetic avenues to these compounds. As the first review on this subject that covers the developments since 1950s to date, it is expected that it will inspire wider implementation of the heterocyclic N-oxide motif in the rational design of new medicinal agents.

Keywords: Heterocyclic N-oxides, nitric oxide mimics, bioisosteres, hypoxia, factor Xa inhibitors, coagulation cascade direct thrombin inhibitors, antichagasic agents, antimalarials.

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Article Details

Year: 2015
Page: [2819 - 2857]
Pages: 39
DOI: 10.2174/0929867322666150619104007
Price: $65

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PDF: 105