The aim of the study was an assessment of the antioxidant, antifungal and cytotoxic potentials
of L. betulinus and T. hirsuta mycelia extracts and the effect of selenium on these activities. Extracts
of L. betulinus were twice as efficient in DPPH• scavenging as those of T. hirsuta. The phenol
content in Se-enriched L. betulinus extracts was higher than in non-enriched extracts, in contrast to the
effect of Se-enrichment on T. hirsuta extracts, and a direct correlation between the amount and DPPH•
scavenging effect was observed. Ethanol extracts exhibited fungistatic but not fungicidal activity
against a range of micromycetes, and mycelium enrichment with selenium inhibited this effect. Although the extracts
showed low cytotoxic activity against HeLa and LS174 cells, T. hirsuta extracts, especially those enriched with selenium,
had better potential. L. betulinuss extracts showed better antioxidant and antifungal activity than T. hirsuta extracts which
were more active cytotoxic agents. The presence of selenium stimulated antioxidant and cytotoxic, and inhibited antifungal
activity in L. betulinus, while in T. hirsuta its effect was slight.
Keywords: Biological activities, Lenzites betulinus, Trametes hirsuta, Mycelium extract, Selenium.
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