FOXM1 and its Oncogenic Signaling in Gastric Cancer

Author(s): Hanying Wang, Chen Huang

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Volume 10 , Issue 3 , 2015

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The transcription factor FOXM1 is overexpressed in many human cancers, including liver, stomach, prostate, brain, breast, lung, colon, pancreas, cervix, ovary and nervous system. Recent data have demonstrated that FOXM1 is involved in cell initiation, progression, and metastasis and in responses to anticancer drugs. In this review, the effects of FOXM1 on gastric cancer, especially the function and regulation of FOXM1 in tumorigenesis and clinical chemotherapy, will be summarized and discussed together with recent relevant patents on the role of FOXM1 in tumor therapy.

Keywords: Cancer therapeutics, FOXM1, gastric cancer, metastasis, progression, transcription factor.

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Article Details

Year: 2015
Page: [270 - 279]
Pages: 10
DOI: 10.2174/1574892810666150617112421
Price: $65

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