Nanolipospheres for Oral Bioavailability Enhancement: Recent Advancements, Current Challenges and Future Directions

Author(s): Suryakanta Swain, Sarwar Beg, Prafulla K. Sahu, Sitty M. Babu, Swaponjit Panda, Mahfoozur Rahman

Journal Name: Current Nanomedicine
(Formerly Recent Patents on Nanomedicine)

Volume 6 , Issue 1 , 2016


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Abstract:

Background: With the revolutionary advent of nanotechnology in 21st century, nanolipospheres have been increasingly viewed as a potential drug carrier for improving gastrointestinal absorption and oral bioavailability of several lipophilic drugs.

Methods: Moreover, these possess advantages with respect to limited toxicity over polymeric nanoparticles and able to deliver drugs with low half-life or low therapeutic index for providing sustained or control drug delivery action.

Results: Considering potential advantages of the nanotechnology for controlling particle size, shape and multi-functionality of drug molecules, nanolipospheres play promising role for attaining improved oral bioavailability of drugs for minimizing the adverse effects.

Conclusion: In this context, the present review article provides details on preparation and application of nanolipospheres-based drug delivery systems for oral bioavailability enhancement of drugs. Besides, the article aims to provide readers as a ready reckoner on current developments in nanoliposphere-based nanomedicines along with future prospects with them in modern drug therapy.

Keywords: Applications, innovation and processing, nanolipospheres, recent patents.

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2016
Published on: 03 March, 2016
Page: [69 - 76]
Pages: 8
DOI: 10.2174/1877912305666150616221523

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