Title:An Insight into Synthetic and Docking Approaches of Benzenesulfonamide Scaffold Revealing COX-2 Inhibitors
VOLUME: 11 ISSUE: 2
Author(s):Sandip D. Firake and Sanjaykumar B. Bari
Affiliation:Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, MS, India.
Keywords:Anti-inflammatory, benzenesulfonamide, COX-2, molecular modeling, pyrazole, synthesis.
Abstract:Benzenesulfonamide is versatile motif employed for the discovery in the field of medicinal
and pharmaceutical chemistry. Over the years of active research, sulfonamide has evolved as
important privileged pharmacophore in medicinal chemistry, encompassing a diverse range of
biological activities including antiviral, carbonic anhydrase inhibitors, diuretic, and a protease
inhibitor, hypoglycemic, anticancer and anti-inflammatory. On the other hand, owing to the fast
development of new drugs possessing sulfonamide pharmacophore many research reports generated in
a short span of time. Thus, there is a need to couple the most recent data with the prior data to
comprehend the present status of benzenesulfonamide as anti-inflammatory agent. The present review highlights the
molecular modeling and synthetic methods of benzenesulfonamide scaffold bearing various heterocyclic or carbocyclic
rings such as thiazole, triazole, imidazole, isoxazoline, pyridine, pyranone, pyridazone, pyrimidine, pyran, indole,
benzothiazole, benzotriazole, benzimidazole and benzopyran as central ring scaffold. In addition to this, the manuscript
will be a guideline to medicinal chemists for rationally designing a novel benzenesulfonamide bearing compounds as
COX-2 inhibitors.
