Collateral Damage: Contribution of Peripheral Inflammation to Neurodegenerative Diseases

Author(s): Antonio J. Herrera, Ana M. Espinosa-Oliva, Maria J. Oliva-Martin, Alejandro Carrillo-Jimenez, Jose L. Venero, Rocio M. de Pablos

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 21 , 2015

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Graphical Abstract:


Neurodegenerative diseases are characterized by a progressive deterioration of brain function, with a consequent significant decline in the quality of life of patients and their families. Due to the concurrent increase in life expectancy, the incidence of these diseases has been increasing over the last years and thus there is a growing interest in finding potential risk factors. This review focuses on the correlation between peripheral inflammatory diseases and neurodegeneration, in particular on the relationship between gastrointestinal disorders and Parkinson's disease, especially through the so called gut-brain axis.

Keywords: Gut-brain axis, Inflammatory bowel disease, Microglia, Neurodegeneration, Parkinson’s disease, Peripheral inflammation.

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Article Details

Year: 2015
Page: [2193 - 2210]
Pages: 18
DOI: 10.2174/1568026615666150610142027
Price: $65

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PDF: 49