Indole and its derivatives are continuously drawing interest of researchers in the field of
medicinal chemistry for development of newer significant moieties due to their wide range of biological
activities. In recent years, indole nucleus has been used to a greater extent for the development of
agents acting on central nervous system (CNS) disorders like epilepsy. Binedaline, Amedalin, Pindolol,
Siramesine and Oxypertine are the marketed drugs used in CNS disorders having indole moiety.
So, keeping this point in mind, the review is specially focused on pharmacological activities of indole
derivatives acting on central nervous system like anticonvulsant, antidepressant and sedative-hypnotic
activities. The present study covers updated information on the most potent indole derivatives during
the past years and also its recent developments. These results may help the researchers to develop novel ideas for future
molecular modifications of indole derivatives with potent pharmacological activities and least side effects may be derived.