A Concise Stereoselective Total Synthesis of (–) - Cephalosporolide D

Author(s): Yapuri Umanadh, Gudaparthi Omprakash, Narahari Srinivasareddy

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 6 , 2015

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Abstract:

A concise stereoselective total synthesis of (-) - Cephalosporolide D, an eight membered lactone ring has been derived from low cost and easily available starting material (±)-propylene epoxide. The key steps involved in this concise synthesis are Sharpless kinetic resolution, Grignard reaction and Yamaguchi macrolactonisation.

Keywords: (±)-propylene epoxide, sharpless kinetic resolution, yamaguchi macrolactonisation, stereoselective synthesis and (-) - cephalosporolide D.

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Article Details

VOLUME: 12
ISSUE: 6
Year: 2015
Published on: 04 June, 2015
Page: [424 - 428]
Pages: 5
DOI: 10.2174/157017861206150604154329
Price: $65

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