In spite of the need for sensing bisdemethoxycurcumin analog
(BDMCA), there is no detection system available so far. For the first time, we have
demonstrated a sensing system for detecting BDMCA. Initially, chitosan thin films
of three different molecular weights (low, average, high) were tested for the
conductivity. The high molecular weight chitosan film was found to produce higher
conductance and hence, used as the substrate. Addition of BDMCA to this substrate
induced a significant conductance change (as revealed by impedance analyzer), making the
detection system qualitative. Addition of increasing concentrations of BDMCA produced
significantly concomitant increase in the conductivity (observed as decrease in current density as
revealed by cyclic voltammetry) making the sensor quantitative. Our results show that this chitosan
based electrochemical sensing system can be used for the rapid quantitative detection of BDMCA.
As there is no BDMCA sensor available so far, this type of detection is very essential to monitor the
pharmacokinetic behavior, the therapeutic dosage, bioavailability and related toxicity of BDMCA in
different formulations and samples.