Title:Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor
VOLUME: 15 ISSUE: 10
Author(s):Christine Basmadjian, Helene Malka-Mahieu and Laurent Desaubry
Affiliation:Laboratory of Therapeutic Innovation (UMR 7200), University of Strasbourg-CNRS, Faculty of Pharmacy, 67401 Illkirch, France.
Keywords:Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.
Abstract:4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like
analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells.
Unexpectedly, 1 was found inactive in both assays.
