Title:Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming
VOLUME: 11 ISSUE: 2
Author(s):Wanqiu Chen, David J. Baylink, K.-H. William Lau and Xiao-Bing Zhang
Affiliation:Division of Regenerative Medicine, Department of Medicine, Loma Linda University. 11234 Anderson Street, MC1528, Loma Linda, CA 92350.
Keywords:Blood, hematopoietic cells, induced pluripotent stem cells, Mesenchymal stem cells, reprogramming.
Abstract:Mesenchymal stem cells (MSCs) have been successfully used to treat multiple diseases in
animal studies and clinical trials. Currently, the commonly used MSCs are derived from bone marrow
and adipose tissue. Alternative approaches include differentiation of induced pluripotent stem cells
(iPSCs) into MSCs, or direct reprogramming of blood cells into MSCs. This review summarizes recent
progresses concerning how to generate MSCs by blood cell reprogramming and how studies in cellular
reprogramming may help identify new factors to expand or even rejuvenate adult MSCs.
