Abstract
This review summarizes recent breakthroughs in studies regarding proliferation of adult stem cells which complement and extend our knowledge to various aspects of cell biology and signal pathways. In recent years, many interesting results and discoveries were achieved regarding the proliferative properties of stem cells. In vitro expansion of stem cells may benefit from high proliferation rates, which can produce a large amount of cells to regenerate tissue defects. Meanwhile, optimizing the culture conditions for stem cell propagation is helpful in maintaining the pluripotency and differentiation potential of stem cells, which are critical for tissue engineering and regenerative medicine. Additionally, understanding the proliferation of stem cells may help us to uncover new mechanisms of drug resistance, since stem cells are believed to play an important role in drug resistance. In this review, we focus on signaling pathways regulating the proliferation of various stem cells isolated from adult tissues. We also emphasize the significance of stem cells proliferation in cell research, as well as rapid propagation of adult stem cells for regenerative medicine.
Keywords: Apoptosis, cell cycle, cell proliferation, dental regeneration, stem cells, tissue regeneration.
Current Stem Cell Research & Therapy
Title:Regulators of Stem Cells Proliferation in Tissue Regeneration
Volume: 11 Issue: 3
Author(s): Chenchen Zhou, Brian E. Grottkau and Shujuan Zou
Affiliation:
Keywords: Apoptosis, cell cycle, cell proliferation, dental regeneration, stem cells, tissue regeneration.
Abstract: This review summarizes recent breakthroughs in studies regarding proliferation of adult stem cells which complement and extend our knowledge to various aspects of cell biology and signal pathways. In recent years, many interesting results and discoveries were achieved regarding the proliferative properties of stem cells. In vitro expansion of stem cells may benefit from high proliferation rates, which can produce a large amount of cells to regenerate tissue defects. Meanwhile, optimizing the culture conditions for stem cell propagation is helpful in maintaining the pluripotency and differentiation potential of stem cells, which are critical for tissue engineering and regenerative medicine. Additionally, understanding the proliferation of stem cells may help us to uncover new mechanisms of drug resistance, since stem cells are believed to play an important role in drug resistance. In this review, we focus on signaling pathways regulating the proliferation of various stem cells isolated from adult tissues. We also emphasize the significance of stem cells proliferation in cell research, as well as rapid propagation of adult stem cells for regenerative medicine.
Export Options
About this article
Cite this article as:
Zhou Chenchen, Grottkau E. Brian and Zou Shujuan, Regulators of Stem Cells Proliferation in Tissue Regeneration, Current Stem Cell Research & Therapy 2016; 11 (3) . https://dx.doi.org/10.2174/1574888X10666150531172108
DOI https://dx.doi.org/10.2174/1574888X10666150531172108 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Is Effective and Safe a Radiochemotherapy Approach in Elderly Cancer Patients? A Review
Anti-Cancer Agents in Medicinal Chemistry A Stack Autoencoders Based Deep Neural Network Approach for Cervical Cell Classification in Pap-Smear Images
Recent Advances in Computer Science and Communications Thiosemicarbazones as Potent Anticancer Agents and their Modes of Action
Mini-Reviews in Medicinal Chemistry The Impact of the Theory-Based Training on Beliefs of Women towards Breast Cancer Screening Behaviors
Current Women`s Health Reviews MicroRNAs in Breast Cancer: One More Turn in Regulation
Current Drug Targets Molecular Evidence of Cryptotanshinone for Treatment and Prevention of Human Cancer
Anti-Cancer Agents in Medicinal Chemistry Molecular Docking and Dynamic Simulation Studies of Terpenoids of I. wightii (Bentham) H. Hara against Acetylcholinesterase and Histone Deacetylase3 Receptors
Current Computer-Aided Drug Design Critical microRNAs in Lung Cancer: Recent Advances and Potential Applications
Anti-Cancer Agents in Medicinal Chemistry Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues
Current Medicinal Chemistry Novel Concepts in the Development of Platinum Antitumour Drugs: An Update
Medicinal Chemistry Reviews - Online (Discontinued) A Review on Recent Technologies and Patents on Silica Nanoparticles for Cancer Treatment and Diagnosis
Recent Patents on Drug Delivery & Formulation Disorders of Consciousness and Electrophysiological Treatment Strategies: A Review of the Literature and New Perspectives
Current Pharmaceutical Design Update of the Preclinical Situation of Anticancer Platinum Complexes: Novel Design Strategies and Innovative Analytical Approaches
Current Medicinal Chemistry Distinct Epigenetic Reprogramming, Mitochondrial Patterns, Cellular Morphology, and Cytotoxicity after Bee Venom Treatment
Recent Patents on Anti-Cancer Drug Discovery Circular RNAs and Glioma: Small Molecule with Big Actions
Current Molecular Medicine Recent Advance in the Research of Flavonoids as Anticancer Agents
Mini-Reviews in Medicinal Chemistry An Analysis of Structure-function Co-relation between GLI Oncoprotein and HLA Immune-gene Transcriptional Regulation through Molecular Docking
Current Cancer Therapy Reviews Trigonelline: A Plant Alkaloid with Therapeutic Potential for Diabetes and Central Nervous System Disease
Current Medicinal Chemistry How to Manage the Infectious Risk under Anti-TNF in Inflammatory Bowel Disease
Current Drug Targets A Facile and Microwave-assisted Rapid Synthesis of 2-Arylamino-4-(3′-indolyl)- thiazoles as Apoptosis Inducing Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry