This review summarizes recent breakthroughs in studies regarding proliferation of adult
stem cells which complement and extend our knowledge to various aspects of cell biology and signal
pathways. In recent years, many interesting results and discoveries were achieved regarding the proliferative
properties of stem cells. In vitro expansion of stem cells may benefit from high proliferation
rates, which can produce a large amount of cells to regenerate tissue defects. Meanwhile, optimizing
the culture conditions for stem cell propagation is helpful in maintaining the pluripotency and differentiation
potential of stem cells, which are critical for tissue engineering and regenerative medicine. Additionally, understanding
the proliferation of stem cells may help us to uncover new mechanisms of drug resistance, since stem cells are
believed to play an important role in drug resistance. In this review, we focus on signaling pathways regulating the proliferation
of various stem cells isolated from adult tissues. We also emphasize the significance of stem cells proliferation in
cell research, as well as rapid propagation of adult stem cells for regenerative medicine.
Keywords: Apoptosis, cell cycle, cell proliferation, dental regeneration, stem cells, tissue regeneration.
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