In recent decades, targeted nano-drug delivery systems have attracted extensive attention in cancer therapy
for their efficient drug delivery and tumor site specificity. Tumor vasculature, including angiogenesis and vasculogenic
mimicry is associated tightly with tumor growth, progression and metastasis. Therefore, nano-drug delivery
systems targeting tumor vasculature are becoming a promising approach for tumor treatment. As complicated
mechanisms and various factors are involved in the tumor vasculature, different ligands modified on the surface
of nanocarriers acquire active targeting through binding to the receptors over-expressed by cancer cells or angiogenic endothelial
cells. In this review, the tumor vasculature characteristics are briefly described and the recent advances and potential strategies in tumor
vasculature targeted nano-drug delivery systems are introduced.
Keywords: Angiogenesis, drug delivery systems, systematic targeted drug delivery, target, tumor vasculature, vasculogenic mimicry.
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