Hyaluronic acid (HA) is a relatively new polymer for the construction of drug delivery systems.
CD44 and the receptor for HA-mediated motility play a key role in vivo for the receptormediated
endocytosis of HA. Cellular uptake and the efficiency of tumor-targeted drug delivery are
supposed to increase through utilizing HA as drug carriers. Currently, HA has provided a promising
platform to physically encapsulate or chemically conjugate with various drugs. In this review, we presented
the most latest advances in HA-based drug delivery systems and some forward-looking ideas
Keywords: CD44, chemical modification, conjugates, derivatives, hyaluronic acid, nanocarriers.
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