Mesenchymal stem cell therapy for inflammatory bowel diseases: promise and challenge

Author(s): Chen Ke, Huang Biao, Liu Qianqian, Sun Yunwei, Jiang Xiaohua

Journal Name: Current Stem Cell Research & Therapy

Volume 10 , Issue 6 , 2015

Become EABM
Become Reviewer

Abstract:

Inflammatory Bowel Disease (IBD) is a complicated disease that arises as a consequence of the interaction among environment, genetic factors and autoimmunity. Available therapeutic interventions with pharmacological or biological drugs have a very selective action. Mesenchymal stem cells (MSCs) have been emerging as a promising cellular therapy for the treatment of IBD due to their multifaceted functions. This article summarizes recent progress in both preclinical studies and clinical trials employing MSCs in IBD treatment. We justify the use of MSC-based cell therapy as a novel strategy for IBD, discuss the biological roles that MSCs play underlying their therapeutic effects focusing on their immune-suppressive effects, illustrate methods to improve MSCs for better repair, and pinpoint the obstacles hindering their success and the challenges to overcome before their ultimate application.

Keywords: Immunomodulation, inflammatory bowel disease, MSC.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 10
ISSUE: 6
Year: 2015
Page: [499 - 508]
Pages: 10
DOI: 10.2174/1574888X10666150528143138
Price: $65

Article Metrics

PDF: 47
HTML: 2