Anti-Cancer Drug Design Using Natural and Synthetic Pharmacophores

Author(s): Pinaki S. Bhadury, Jun Pang

Journal Name: Current Organic Chemistry

Volume 19 , Issue 15 , 2015

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Graphical Abstract:


Despite incredible advancement made in recent years, treatment of cancer still remains the most challenging task for the mankind. The new small molecule therapeutic drugs are more specific, exhibit better therapeutic efficacy and mostly contain scaffolds of β-lactam, sulfonamide, quinoline, quinazoline, quinoxaline, purine, pyrimidine, resorcinol, pyrazole/isoxazole, benzamide etc. The structure-activity relationships of different pharmacophores that have been reported to potently inhibit cell growth of human tumour cell lines are constantly being investigated. Development of products of natural origin can also prove effective without submitting to harmful radiation and chemotherapy treatments. Under these circumstances, the practicing organic chemists are greatly facing the challenge of designing new and leading anti-cancer drugs based on natural products and scaffolds of potent pharmacaophores. The review intends to cover new approach of anti-cancer drug design using natural and synthetic pharmacophores. The plausible synthetic routes to major drugs for oncology that were approved recently by Food and Drug Administration (FDA) are also discussed.

Keywords: Anti-cancer drug, phamacophoric scaffold, oncology, synthesis, natural & herbal product, hybrid drug, FDA-approved drug.

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Article Details

Year: 2015
Published on: 08 July, 2015
Page: [1460 - 1490]
Pages: 31
DOI: 10.2174/1385272819666150525234749
Price: $58

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PDF: 37