Radiolabeled Sugars Used for PET and SPECT Imaging

Title:Radiolabeled Sugars Used for PET and SPECT Imaging

VOLUME: 9 ISSUE: 3

Author(s):Brianda Barrios-Lopez and Kim Bergstrom

Affiliation:Helsinki University Central Hospital, HUS Medical Imaging Center, POB 340, FI-00029 HUS, Finland.

Keywords:Alzheimer’s disease imaging, cancer imaging, glucose metabolism imaging, radiolabeled glucose analogs.

Abstract:There are new efforts to develop “sugar” probes for molecular imaging focusing on human clinical studies. Radiolabeled carbohydrates are used as substrate probes for studying specific processes in tissues and organisms. The best application case is 2-Deoxy-2-[¹⁸F]fluoro-D-glucose (¹⁸F-FDG), which is incorporated by cancer cells. The introduction of ¹⁸F-FDG has advanced enormously human Positron Emission Tomography (PET). This review focuses on the importance of ¹⁸FFDG and other sugars as imaging probes in PET and Single Photon Emission Computed Tomography (SPECT) imaging. In conclusion, new radiolabeled molecules that can be used as radiopharmaceuticals also would possibly help in the treatment of cancer cells in human patients.

Cite this article as:

Brianda Barrios-Lopez and Kim Bergstrom, “Radiolabeled Sugars Used for PET and SPECT Imaging”, Current Radiopharmaceuticals (2016) 9: 180. https://doi.org/10.2174/1874471008666150525104725

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