Title:Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls
VOLUME: 15 ISSUE: 9
Author(s):Seyed Fazel Nabavi, Kasi Pandima Devi, Dicson Sheeja Malar, Antoni Sureda, Maria Daglia and Seyed Mohammad Nabavi
Affiliation:Department of Biotechnology, Alagappa University, Karaikudi-630 004, Tamil Nadu, India.
Keywords:Alzheimer’s disease, antioxidant, ferulic acid, neurodegeneration, oxidative stress.
Abstract:Oxidative stress plays an important role in both initiation and progression
of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much
attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However,
as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products
especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial
role of ferulic acid on Alzheimer’s disease, since it is a natural antioxidant which is widely found in different fruits and
vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of
ferulic acid.
