Abstract
Histone Deacetylase (HDAC) is an established and validated target for the treatment of cancer. It has been attempted to present a comprehensive review on the inhibitors for Class-I Histone Deacetylase enzyme family, reported during the period from 2002 to 2012. This review has summarized the inhibitors, based on their specificity towards different isoforms within this class. Further various recent United State (US) patents and the HDAC inhibitors, used singly or in combination undergoing clinical trial as anticancer agents have been reviewed. Three such inhibitors SAHA, Romidepsin and Belinostat have already been approved by the US-FDA for the treatment of cancer.
Keywords: Histone Deacetylase, cancer, isoform, Romidepsin, US-FDA.
Mini-Reviews in Medicinal Chemistry
Title:Histone Deacetylase Inhibitors: A Review on Class-I Specific Inhibition
Volume: 15 Issue: 9
Author(s): Jagannath Behera, Venkatesan Jayaprakash and Barij Nayan Sinha
Affiliation:
Keywords: Histone Deacetylase, cancer, isoform, Romidepsin, US-FDA.
Abstract: Histone Deacetylase (HDAC) is an established and validated target for the treatment of cancer. It has been attempted to present a comprehensive review on the inhibitors for Class-I Histone Deacetylase enzyme family, reported during the period from 2002 to 2012. This review has summarized the inhibitors, based on their specificity towards different isoforms within this class. Further various recent United State (US) patents and the HDAC inhibitors, used singly or in combination undergoing clinical trial as anticancer agents have been reviewed. Three such inhibitors SAHA, Romidepsin and Belinostat have already been approved by the US-FDA for the treatment of cancer.
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Behera Jagannath, Jayaprakash Venkatesan and Sinha Nayan Barij, Histone Deacetylase Inhibitors: A Review on Class-I Specific Inhibition, Mini-Reviews in Medicinal Chemistry 2015; 15 (9) . https://dx.doi.org/10.2174/1389557515666150521162237
DOI https://dx.doi.org/10.2174/1389557515666150521162237 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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