Recent Advances in the Membrane Receptor Initiated Vitamin D Signaling of Calcium and Phosphate Transport Across Intestinal and Kidney Epithelia

Author(s): Ramesh C. Khanal, Yang Zhang, Ilka Nemere

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents

Volume 14 , Issue 3 , 2014


The 1,25D3-MARRS receptor is bioidentical with protein disulfide isomerase A3, and has been demonstrated to be required for the rapid, pregenomic actions of the steroid hormone 1,25D3 on calcium and phosphate uptake in a number of tissues. In this review we discuss the role of this receptor as it relates to the recent advances in calcium and phosphate transport along with its role in select disease states. We also review that another metabolite, 24,25D3, also has biological activity.

Keywords: Calcium, phosphate, vitamin D, 1, 25D3-MARRS receptor, ERp57/GRp58, cancer, Alzheimer’s.

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Article Details

Year: 2014
Published on: 20 May, 2015
Page: [171 - 180]
Pages: 10
DOI: 10.2174/187152221403150521110022
Price: $58

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