The 1,25D3-MARRS receptor is bioidentical with protein disulfide isomerase A3, and has been
demonstrated to be required for the rapid, pregenomic actions of the steroid hormone 1,25D3 on calcium and
phosphate uptake in a number of tissues. In this review we discuss the role of this receptor as it relates to the
recent advances in calcium and phosphate transport along with its role in select disease states. We also review
that another metabolite, 24,25D3, also has biological activity.
Keywords: Calcium, phosphate, vitamin D, 1, 25D3-MARRS receptor, ERp57/GRp58, cancer,
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