Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi

Author(s): Hao-Yu Tang, Xia Yin, Cheng-Chen Zhang, Qian Jia, Jin-Ming Gao

Journal Name: Current Medicinal Chemistry

Volume 22 , Issue 19 , 2015

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Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon scaffold, including 105 members reported to date. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses on the structure diversity, structure elucidation and biological studies of these compounds, including mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis of cyathane diterpenoids is discussed.

Keywords: Basidiomycete, cyathane diterpenes, enantioselective synthesis, mushroom, natural products, NGF synthesis inducers, structure-activity relationships.

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Article Details

Year: 2015
Page: [2375 - 2391]
Pages: 17
DOI: 10.2174/0929867322666150521091333
Price: $65

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